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Offer:  Master of Science by research

Title:  Genetic Polymorphism of lipid related gene-associated Familial Hypercholesterolemia in Bidayuh and  Iban ethnic groups in Sarawak

Synopsis:

Familial Hypercholesterolemia (FH) is one of the most common inherited disorders, with an estimated worldwide prevalence of 1 in 500 (0.2%), though the frequency is considerably higher in some populations because of a founder effect. Single nucleotide polymorphisms of certain Low Density Lipoprotein Receptor gene (LDLR), Apolipoprotein B (APOB), Pro-protein Convertase Subtilisin or Kexin type IX (PCSK9) and Upstream Transcription Factor 1 gene (USF1) have been reported to be higher in FH patients compared to normal controls in Malaysian population. Our research question is; what are the frequencies of the aforementioned lipid related gene in Bidayuh and Iban ethnic groups in Sarawak? Insofar there is no information on the relationship between FH and polymorphism of lipid related gene among Bidayuh and Iban ethnic groups in Sarawak as no previous studies have been conducted. Therefore, the present study is designed to investigate genetic polymorphisms of a few lipid related genes (genes which are found to be important for familial hypercholesterolemia in Malaysian population) in Bidayuh and Iban ethnic groups in Sarawak and to elucidate the association of the polymorphic genotypes with other clinical profiles of aforementioned ethnics groups. DNA from the peripheral blood of the study subjects will be extracted and the genes of interest will be PCR-amplified using appropriate primers and PCR conditions. All single nucleotide polymorphisms in this study will be determined by using allele specific PCR. Early detection can help significantly in better treatment outcomes for FH. Consequently, identifying predisposing genetic variations is important to our understanding of the FH process. Systematic genetic screening for mutations for those at risk of FH can be cost effective and can result in better prognosis.

Supervisors:  Associate Professor Dr. Samirah Abdullah @ Sim Sai Peng and Mr. Mohd Aminudin Bin Mustapha

Contact:  Dr. Samirah Abdullah: email: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

Anyone interested please email to enquire, please attach a CV.

Read 1916 times Last modified on Monday, 18 November 2013 08:51

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